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Cytoplasm vs. Protoplasm: Know the Difference

Shumaila Saeed
By Shumaila Saeed || Updated on December 25, 2023
Cytoplasm is the jelly-like substance inside a cell's membrane excluding the nucleus, while protoplasm encompasses both the cytoplasm and the nucleus.
Cytoplasm vs. Protoplasm

Key Differences

Cytoplasm refers to the thick, jelly-like material that makes up much of a cell’s interior, found within the cellular membrane but outside the nucleus. In contrast, protoplasm includes both the cytoplasm and the cell nucleus, encompassing the entire contents of a cell.
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The cytoplasm is the site of many crucial cellular processes such as glycolysis and acts as a medium where organelles are suspended. Protoplasm, being more inclusive, encompasses all the vital components of a cell, including the cytoplasm and the nucleus where genetic material is stored.
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Cytoplasm contains various organelles like mitochondria, ribosomes, and the endoplasmic reticulum, responsible for distinct cellular functions. Protoplasm, on the other hand, extends beyond to include the cell's genetic center, the nucleus, providing a holistic view of the cell's internal environment.
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The concept of cytoplasm is more specific, focusing on the cellular region outside the nucleus. Protoplasm is a more general term, often used to describe the essential living components of a cell, giving a broader biological context.
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In terms of functionality, the cytoplasm plays a key role in maintaining cell structure and shape, aiding in intracellular transport. Protoplasm represents the living part of the cell, crucial for maintaining life processes and cellular integrity.
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Comparison Chart

Definition

The jelly-like material inside a cell, excluding the nucleus
The entire contents of a cell, including both the cytoplasm and the nucleus
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Contains

Organelles like mitochondria, ER, ribosomes
Cytoplasm, nucleus, and all cell organelles
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Function

Supports chemical processes, provides medium for organelles
Encompasses all vital life processes of the cell
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Location

Within the cell membrane but outside the nucleus
Extends throughout the entire cell
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Focus

Specific to cell’s structural and metabolic activities
General, representing the essential living part of the cell
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Cytoplasm and Protoplasm Definitions

Cytoplasm

This component is essential for maintaining cell structure.
The cytoplasm helps give the cell its shape.
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Protoplasm

It encompasses all the vital elements of a cell.
Genetic information within the protoplasm controls cell functions.
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Cytoplasm

It plays a crucial role in cellular metabolism.
Glycolysis, a metabolic process, occurs in the cytoplasm.
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Protoplasm

Protoplasm is the living content of a cell, including the cytoplasm and nucleus.
Protoplasm is fundamental to all life processes in the cell.
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Cytoplasm

Cytoplasm is the fluid substance in a cell, excluding the nucleus.
Cellular reactions like enzyme activities occur within the cytoplasm.
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Protoplasm

Protoplasm is the site for all cellular activities.
Cell division begins in the protoplasm.
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Cytoplasm

Cytoplasm facilitates intracellular transport and chemical reactions.
Nutrients are distributed to organelles through the cytoplasm.
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Protoplasm

This term represents the physical basis of life in cells.
The study of protoplasm provides insights into cellular life.
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Cytoplasm

It's the medium that holds cell organelles in place.
Mitochondria float in the cytoplasm of the cell.
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Protoplasm

Protoplasm is crucial for maintaining the integrity of cellular life.
Damage to the protoplasm can lead to cell death.
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Cytoplasm

The protoplasm enclosed by the plasma membrane of cell, excluding the nucleus in eukaryotic cells and cellular DNA in prokaryotic cells.
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Protoplasm

The complex, semifluid, translucent substance that constitutes the interior matter of a living cell and is composed of proteins, fats, and other molecules suspended in water. It includes the cytoplasm, the nucleus in eukaryotes, and organelles such as mitochondria.
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Cytoplasm

(cytology) The contents of a cell except for the nucleus. It includes cytosol, organelles, vesicles, and the cytoskeleton.
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Protoplasm

(cytology) The entire contents of a cell comprising the nucleus and the cytoplasm. It is a semi-fluid, transparent substance which is the living matter of plant and animal cells.
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Cytoplasm

The substance of the body of a cell, as distinguished from the karyoplasma, or substance of the nucleus.
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Protoplasm

The viscid and more or less granular material of vegetable and animal cells, possessed of vital properties by which the processes of nutrition, secretion, and growth go forward; the so-called " physical basis of life;" the original cell substance, cytoplasm, cytoblastema, bioplasm sarcode, etc.
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Cytoplasm

The protoplasm of a cell excluding the nucleus
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Protoplasm

The living substance of a cell (including cytoplasm and nucleus)
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Repeatedly Asked Queries

Where is the cytoplasm located?

Between the cell membrane and the nuclear envelope.
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Can substances move freely within the cytoplasm?

Yes, substances can move freely within the cytoplasm, allowing for the transport of materials within the cell.
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How does cytoplasm relate to cell division?

During cell division, the cytoplasm is divided equally between daughter cells in a process called cytokinesis.
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What is cytoplasm?

A jelly-like substance inside cells, excluding the nucleus.
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How does protoplasm differ from cytoplasm?

Protoplasm encompasses both the cytoplasm and the nucleoplasm (inside the cell nucleus).
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Can the cytoplasm vary in consistency between different cell types?

Yes, the consistency of cytoplasm can vary between cell types and can range from more fluid-like to more gel-like.
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Can protoplasm exhibit movement and responsiveness to stimuli?

Yes, protoplasmic movement and responsiveness to stimuli are essential characteristics of living cells.
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What does protoplasm include?

Both the cytoplasm and the nucleus of a cell.
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What are the major components of protoplasm?

Protoplasm consists of water, proteins, lipids, carbohydrates, and nucleic acids.
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Can protoplasmic properties vary among different cell types and organisms?

Yes, the properties and composition of protoplasm can vary among different cell types, organisms, and environmental conditions.
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What is the role of ribosomes in the cytoplasm?

Ribosomes, which are involved in protein synthesis, are often found in the cytoplasm.
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Is protoplasm found in all living cells?

Yes, protoplasm is present in all living cells, whether they are prokaryotic or eukaryotic.
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Can protoplasm change its composition under different physiological conditions?

Yes, protoplasm can adapt its composition and activities based on the needs of the cell.
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Is cytoplasm found in both eukaryotic and prokaryotic cells?

Yes, cytoplasm is present in both eukaryotic and prokaryotic cells.
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Is protoplasm considered the physical basis of life?

Yes, protoplasm is often referred to as the physical basis of life due to its role in maintaining living processes.
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Where is cytoplasm located within a cell?

Cytoplasm is found throughout the entire cell, including the region outside the cell nucleus.
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What is the relationship between protoplasm and metabolism?

Protoplasm houses the metabolic machinery of the cell, where various biochemical reactions occur.
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What is the composition of cytoplasm?

Cytoplasm consists of water, salts, proteins, and various molecules necessary for cellular processes.
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About Author
Shumaila Saeed
Written by
Shumaila Saeed
Shumaila Saeed, an expert content creator with 6 years of experience, specializes in distilling complex topics into easily digestible comparisons, shining a light on the nuances that both inform and educate readers with clarity and accuracy.

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