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Difference between Sense and Antisense Strand of DNA

Main Difference

DNA molecule is a double helix strand which moreover embrace histones. Sense and antisense are the two strands of DNA. The foremost between sense and antisense is, primarily based totally on transcription or on the strand that serves as template for mRNA, one of the strand is called sense whereas the alternative one is called antisense.

Sense Strand of DNA

The sense strand of DNA has the equivalent base sequence as a result of the mRNA. But it has thymine as an alternative of uracil. This strand is called coding strand, plus strand or non-template strand. Uracil is present in RNA as an alternative of thymine which is present in DNA. Moreover, it has related base sequence as tRNA. It actually runs from 5 primer to a few primer and is complementary to the antisense strand. This strand undergoes translation and the moment final result of this course of is RNA transcript. The translated protein may be inherited by this strand and that is one of the reason why mRNA is wise with the genetic code. Most of the events eukaryotic RNA undergoes additional enhancing sooner than translating to proteins, on this course of introns are eradicated and methylated guanine is added at one end. Additional poly-A tail is added to the alternative end and we time interval this course of as splicing.

Antisense Strand of DNA

The template strand which is transcribed is called antisense strand of DNA. This strand will be termed as minus strand, non-coding strand or template strand. It is complementary strand to the sense strand and mRNA. Uracil is present in RNA as an alternative of thymine. This strand carries knowledge that is important for the manufacture of proteins by binding to corresponding mRNA. These strand are alike and solely these strand are succesful of giving knowledge for the synthesis of protein. It does get transcribed not like sense strand and it would not have the equivalent base sequence as tRNA.

Key Differences

  • Sense strand is coding strand whereas antisense strand is non-coding.
  • Sense strand is analogous as mRNA nevertheless thymine in DNA is modified by uracil in RNA. On the alternative hand, antisense strand acts as template for RNA synthesis.
  • Sense strand has codons and antisense strand has non-codons.
  • In sense strand the nucleotides are linked by hydrogen bonding all through transcription nevertheless throughout the case of antisense strand, nothing such occurs.
  • Sense strand would not has related sequence as mRNA nevertheless antisense strand does.
  • Sense strand has related base sequence as tRNA nevertheless antisense would not.

Video Explanation

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